PubAg

Main content area

Photobiocatalyzed asymmetric reduction of ketones using Chlorella sp. MK201

Author:
Itoh, Ken-ichi, Nakamura, Kaoru, Aoyama, Tadashi, Matsuba, Ryusuke, Kakimoto, Tsuyoshi, Murakami, Masahiko, Yamanaka, Rio, Muranaka, Toshiya, Sakamaki, Hiroshi, Takido, Toshio
Source:
Biotechnology letters 2012 v.34 no.11 pp. 2083-2086
ISSN:
0141-5492
Subject:
Chlorella, fluorescent lighting, ketones
Abstract:
Aromatic ketones were reduced using suspension culture of Chlorella sp. MK201 under fluorescent light illumination producing the corresponding chiral alcohols in high yields with excellent enantiomeric excess (ee). For example, 2′,3′,4′,5′,6′-pentafluoroacetophenone at 0.25 mg/ml was converted to the corresponding (S)-alcohol in 80 % yield with >99 % ee by 1 mg dry wt of Chlorella/ml in 12 h illumination (2,000 lux).
Agid:
440052