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A new dimeric neolignan from Magnolia grandiflora L. seeds

Author:
Li, Hong-Mei, Zhao, Su-Rong, Huo, Qiang, Ma, Tao, Liu, Hao, Lee, Jae kyoung, Hong, Young-Soo, Wu, Cheng-Zhu
Source:
Archives of pharmacal research 2015 v.38 no.6 pp. 1066-1071
ISSN:
0253-6269
Subject:
Magnolia grandiflora, apoptosis, caspase-3, fractionation, honokiol, human cell lines, humans, inhibitory concentration 50, magnolol, methanol, nuclear magnetic resonance spectroscopy, pro-apoptotic proteins, seeds
Abstract:
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC₅₀ values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.
Agid:
4405299