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Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats

Mnafgui, Kais, Derbali, Amal, Sayadi, Sami, Gharsallah, Neji, Elfeki, Abdelfattah, Allouche, Noureddine
Journal of food science and technology 2015 v.52 no.7 pp. 4369-4377
antihypertensive effect, aorta, atherosclerosis, blood lipids, blood serum, body weight changes, carboxylic ester hydrolases, cardioprotective effect, cinnamic acid, diabetes mellitus, diet, digestive enzymes, echocardiography, fatty liver, hyperlipidemia, hypertension, kidneys, leptin, lipid composition, low density lipoprotein cholesterol, males, neoplasms, obesity, peptidyl-dipeptidase A, rats, toxicity, triacylglycerols, vasoconstriction
Obesity is a chronic metabolic disorder that is associated with numerous diseases including hyperlipidemia, diabetes mellitus, hypertension, atherosclerosis, cardiovascular disease, and cancer. Cinnamic acid is a phytochemical compound having many biological effects and could be considered for the management of obesity. This study is aimed to assess the possible anti-obesity and cardioprotective properties of cinnamic acid (CA) in high fat diet-fed rats (HFD). Male Wistar rats were divided into 4 groups. They received normal diet, HFD diet, HFD supplemented with fluvastatin (2 mg/kg/day) or cinnamic acid (30 mg/kg/day) for 7 weeks. The results showed an increase in body weight of HFD rats by ~27 % as compared to control group. Moreover, serum lipase activity underwent a significant rise by 103 % which led to an increase in the levels of total cholesterol (T-Ch), triglycerides (TG), LDL-cholesterol in serum of untreated HFD-fed rats. Furthermore, the concentration of leptin and angiotensin-converting enzyme (ACE) activity exhibited remarkable increases in serum of HFD-fed rats as compared to controls. Whereas, the administration of CA to HFD-fed rats improved the body weight gain and serum lipid profile and reverted back near to normal the activities of lipase and ACE. In addition, the echocardiography evidenced that CA is able to protect the aorta and aortic arch and avoided vasoconstriction by increasing their diameters and improved liver steatosis and kidney indices of toxicity. Overall, these results suggest that cinnamic acid exerts anti-obesity and antihypertensive effects through inhibition of lipid digestive enzymes and ACE.