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Advanced glycation end products inhibitors from Alpinia zerumbet rhizomes

Author:
Chompoo, Jamnian, Upadhyay, Atul, Kishimoto, Wataru, Makise, Tadahiro, Tawata, Shinkichi
Source:
Food chemistry 2011 v.129 no.3 pp. 709-715
ISSN:
0308-8146
Subject:
rutin, glycation, hexane, diabetes, Alpinia zerumbet, rhizomes, quercetin
Abstract:
Advanced glycation end products (AGEs) are major factors responsible for the complication of diabetes. The present study was carried out to investigate the inhibitory activities on fructosamine adduct and α-dicarbonyl formations by hexane extracts of various parts of Alpinia zerumbet. Furthermore, we isolated two previously known compounds, namely 5,6-dehydrokawain (DK) and dihydro-5,6-dehydrokawain (DDK). 8(17),12-Labdadiene-15,16-dial (labdadiene) was isolated for the first time from the rhizome of A. zerumbet. The results showed that labdadiene (IC₅₀=51.06μg/mL) had similar activity to rutin and quercetin against fructosamine adduct. The inhibition of α-dicarbonyl compounds formation by labdadiene was significantly higher than that of DK and DDK. Our results indicate that labdadiene is a potent antiglycation agent which was found to inhibit AGEs formation in three different steps in the pathway. These data indicate that labdadiene could be used to prevent glycation-associated complications in diabetes.
Agid:
441657