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Evaluation of antihyperglycemic activity of Cocos nucifera Linn. on streptozotocin induced type 2 diabetic rats

Author:
Naskar, Sagar, Mazumder, Upal K., Pramanik, Goutam, Gupta, Malaya, Suresh Kumar, R.B., Bala, Asis, Islam, Aminul
Source:
Journal of ethnopharmacology 2011 v.138 no.3 pp. 769-773
ISSN:
0378-8741
Subject:
Cocos nucifera, adverse effects, antioxidants, biomarkers, blood glucose, cardioprotective effect, cholesterol, coconuts, diabetes, diarrhea, glibenclamide, hypoglycemic agents, inflorescences, juices, lipid peroxidation, rats, streptozotocin, sugars, superoxide dismutase, triacylglycerols
Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Cocos nucifera Linn. (Arecaceae) is commonly known as coconut. Traditionally the juice of the young spadix when fresh is used in diarrhea and diabetes. The objective of the present study was to investigate the effect of antidiabetic activity and effect on lipid profile as well as cardioprotective effect of hydro-methanol extract of Cocos nucifera (HECN) on streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: After 72h of STZ (50mg/kg, b.w. i.p.) administration, animals showing plasma sugar level more than 250mg/dl were considered as diabetic rat. Fasting blood glucose (FBG) levels were measured on 0th (after 72h of STZ), 5th, 10th, and 15th day. On the 15th day all the animals were sacrificed and the serum biochemical parameters and antioxidant enzyme status were measured. RESULTS: HECN treated animals showed a significant reduction in FBG level as compared with diabetic control group. Serum enzyme level (SGOT, SGPT, SALP), lipid peroxidation and antioxidant enzyme level such as CAT, GSH, SOD and cholesterol and triglycerides in the HECN treated groups were restored towards normal level as compared to diabetic control groups and the values were comparable with the standard groups (glibenclamide). CONCLUSION: Improvement in the FBG and the restoration of all other biomarker as well as enzymes indicates that HECN has very good antidiabetic activity with very low side effects and provides a scientific rationale for the use as an antidiabetic agent.
Agid:
441782