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The effect of copper and cadmium on 65Zn absorption in zinc-deficient and zinc-supplemented rats
- Evans, G.W., Grace, Carrie I., Hahn, Carole
- Bioinorganic chemistry 1974 v.3 no.2 pp. 115
- zinc, intestinal absorption, small intestine, nutrient deficiencies, copper, cadmium, nutrient-nutrient interactions, radionuclides, dietary mineral supplements, mineral metabolism, intestinal mucosa, rats
- The effect or oral copper and cadmium on65Zn transport to the carcass and65Zn uptake by the small intestine was examined in zinc deficient and zinc supplemented rats. Neither copper nor cadmium, when administered orally with65Zn Zn in ratios of 1000:1, 100:1, or 10:1, affected65Zn transport to the carcass in zinc deficient rats, but both elements inhibited65Zn transport to the carcass in zinc supplemented rats. Copper had little or no effect on65Zn uptake by the intestine in either group, whereas cadmium markedly decreased intestinal65Zn uptake in both deficient and supplemented rats. The experimental results suggest that zinc absorption consists of 2 independent processes: (a) zinc uptake by the intestinal epithelial cells and (b) zinc transport from the lumen to the blood.