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Hypocholesterolemia due to sodium phytate
- Klevay, L.M.
- Nutrition reports international 1977 v.15 no.5 pp. 587
- rats, hypocholesterolemia, phytic acid, antinutritional factors, dietary minerals, zinc, copper, mineral metabolism, myocardial infarction, diet, vegetables, dietary fiber, dietary nutrient sources, cardioprotective effect, risk factors, epidemiological studies, animal models, blood lipids, cholesterol
- For 152 days 40 male Carworth rats were given a diet of sucrose 62, egg white 20 and maize oil 10% with minerals, fibre and vitamins to which was added CuSO4.5H2O 9.95 or 1.246 mg/kg, sodium phosphates 19.6 g/kg or sodium phytate 20 g/kg, to give diets with Zn:Cu ratios of 4.5 and 14.5:1 both with phytate or with phosphates. At 122 and 152 days both groups given phytate had significantly less cholesterol in plasma than those given phosphates, but the Zn:Cu ratio in the diet seemed to have no effect. The Zn:Cu ratio in hair of rats was less in those given phytate than in those given phosphates. Phytate decreased Zn in hair by 33%. Rats given phytate had about 17% more Cu than those given phosphates. By day 117 rats on sodium phytate weighed 16% less than those on sodium phosphates; the Zn:Cu ratio in the diet had no effect on weight.