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Hypocholesterolemia due to sodium phytate

Author:
Klevay, L.M.
Source:
Nutrition reports international 1977 v.15 no.5 pp. 587
ISSN:
0029-6635
Subject:
rats, hypocholesterolemia, phytic acid, antinutritional factors, dietary minerals, zinc, copper, mineral metabolism, myocardial infarction, diet, vegetables, dietary fiber, dietary nutrient sources, cardioprotective effect, risk factors, epidemiological studies, animal models, blood lipids, cholesterol
Abstract:
For 152 days 40 male Carworth rats were given a diet of sucrose 62, egg white 20 and maize oil 10% with minerals, fibre and vitamins to which was added CuSO4.5H2O 9.95 or 1.246 mg/kg, sodium phosphates 19.6 g/kg or sodium phytate 20 g/kg, to give diets with Zn:Cu ratios of 4.5 and 14.5:1 both with phytate or with phosphates. At 122 and 152 days both groups given phytate had significantly less cholesterol in plasma than those given phosphates, but the Zn:Cu ratio in the diet seemed to have no effect. The Zn:Cu ratio in hair of rats was less in those given phytate than in those given phosphates. Phytate decreased Zn in hair by 33%. Rats given phytate had about 17% more Cu than those given phosphates. By day 117 rats on sodium phytate weighed 16% less than those on sodium phosphates; the Zn:Cu ratio in the diet had no effect on weight.
Agid:
44866
Handle:
10113/44866