PubAg

Main content area

A new hepoprotective saponin from Semen Celosia cristatae

Author:
Sun, Zhen-Liang, Gao, Gang-Long, Xia, Yin-Fang, Feng, Jing, Qiao, Zeng-Yong
Source:
Fitoterapia 2011 v.82 no.4 pp. 591-594
ISSN:
0367-326X
Subject:
Celosia, carbon tetrachloride, hepatoprotective effect, nuclear magnetic resonance spectroscopy, physicochemical properties, semen
Abstract:
A new triterpenoid saponin, named semenoside A (1), was isolated from Semen Celosia cristatae. Its structure was elucidated on the basis of 1D, 2D NMR, HR-FAB-MS and ESI-MS techniques, and physicochemical properties. The hepatoprotective activity of semenoside A with an oral dose of 1.0, 2.0 and 4.0mg/kg, respectively, were investigated by carbon tetrachloride (CClâ‚„)-induced hepatotoxicity in mice. The results indicated that it had significant hepatoprotective effects (p<0.01).
Agid:
454860