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Plasma lecithin:cholesterol acyltransferase in copper-deficient rats
- Lau, B.W.C., Klevay, L.M.
- Journal of nutrition 1981 v.111 no.10 pp. 1698
- phosphatidylcholine-choline acyltransferase, enzyme activity, dietary minerals, copper, nutrient deficiencies, kidneys, skeletal muscle, rats, animal disease models, human nutrition, human health, blood serum, phosphatidylcholines, cholesterol acyltransferase, risk factors, myocardial ischemia, males, anemia (disease), hypercholesterolemia
- Some groups of people with high risk of ischemic heart disease have low lecithin:cholesterol acyltransferase activity in plasma and vice versa. Because we hypothesized a relationship between inadequate copper nutriture and the risk of ischemic heart disease, we measured plasma lecithin: cholesterol acyltransferase in copper deficient male Sprague-Dawley rats. Deficiency was verified by the presence of anemia, hypercholesterolemia and low copper concentrations in kidney and skeletal muscle. Three experiments showed a significant decrease (22-32% reduction) in enzyme activity in deficiency. Copper may be required for the synthesis of the enzyme or as a constituent of the enzyme.