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Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats

Herrera, Cristina, García-Barrantes, Pedro M., Binns, Franklin, Vargas, Marianela, Poveda, Luis, Badilla, Sandra
Journal of ethnopharmacology 2011 v.133 no.2 pp. 907-910
Solanaceae, alloxan, blood glucose, filtrates, freeze drying, glucose oxidase, glucose tolerance, glycemic effect, herbal medicines, leaves, models, rats, shrubs
AIM OF THE STUDY: Witheringia solanacea is a small shrub that belongs to the Solanaceae family. The plant is used as an antidiabetic in Costa Rican herbal medicine. The aim of this study was to evaluate the hypoglycemic and antihyperglycemic activity of the aqueous extract of W. solanacea leaves in rodent models. MATERIALS AND METHODS: A crude extract of W. solanacea leaves was prepared in boiling water and the aqueous filtrate was lyophilized. A single oral dose of 250, 500 and 1000mg/kg of the extract was evaluated for hypoglycemic activity in a glucose tolerance test in normal rats and for antihyperglycemic activity in alloxan-induced (140mg/kg) diabetic rats. The blood glucose level was determined at different times by the glucose oxidase method. RESULTS: Dosage of 500 and 1000mg/kg of the extract significantly decreased (p<0.05) blood glucose levels in the glucose tolerance test in normal rats after 1h, there was no significant difference observed at 250mg/kg. Dose of 500mg/kg of the extract significantly reduced (p<0.05) blood glucose levels in alloxan induced hyperglycemic rats at 4 and 5h. CONCLUSIONS: In the present study, the hypoglycemic and antihyperglycemic potential of the W. solanacea was demonstrated in rats. These results give support to the traditional use of W. solanacea as antidiabetic herbal medicine.