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Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro
- Kim, Ha-Yeong, Kim, Hye Mi, Ryu, Byeol, Lee, Jae-Seung, Choi, Jung-Hye, Jang, Dae Sik
- Archives of pharmacal research 2015 v.38 no.11 pp. 1963-1969
- Eclipta prostrata, aerial parts, animal ovaries, chemical structure, cytotoxicity, flavonoids, humans, neoplasm cells, ovarian neoplasms, saponins, thiophenes, triterpenoids
- A new terthiophene, 3′-hydroxy-2,2′:5′,2″-terthiophene-3′-O-β-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2–6), seven triterpenoids (8–14), two coumestans (15 and 16), and four flavonoids (17–20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1–20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.