PubAg

Main content area

Hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in carbon tetrachloride induced hepatotoxicity in rats

Author:
Gomes, Antony, Alam, Mohammed Aftab, Datta, Poulami, Bhattacharya, Shamik, Gomes, Aparna
Source:
Journal of ethnopharmacology 2011 v.138 no.1 pp. 228-232
ISSN:
0378-8741
Subject:
alkaline phosphatase, bilirubin, blood, carbon tetrachloride, hepatoprotective effect, hepatotoxicity, histopathology, liver, markets, medicine, models, oral administration, proteins, rats, snails, superoxide dismutase, triacylglycerols
Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE: In the folk-traditional medicine, snails were used to purify blood, boost immune system, prevent conjunctivitis and to treat liver problems. OBJECTIVES: To evaluate the hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in male Wistar rats treated with carbon tetrachloride as an hepatotoxicant. MATERIALS AND METHODS: Live adult Bellamia bengalensis was collected commercially from the Kolkata market. Aqueous flesh extract (BBE) was prepared in 0.9% saline and expressed in terms of wet weight basis. The aqueous flesh extract was administered orally (1, 2gkg⁻¹day⁻¹) to male rats for 12 days. Liv52 was used as positive control. 24h after administration of extract, the rats were given a single oral dose of CCl₄ (1.25mlkg⁻¹), except vehicle control rats. After 24h of CCl₄ administration, all the animals were sacrificed to collect the blood and liver tissue. RESULTS: BBE (1 and 2gkg⁻¹day⁻¹, p.o.×12 days) significantly prevented CCl₄ induced elevation of SGOT, SGPT, γGT, ACP, ALP, bilirubin, LDH and CCl₄ induced decrease in total protein, triglyceride level in male Wistar rats. BBE treated rat liver anti-oxidant parameters (LPO, SOD, GSH, CAT, GPx) were significantly antagonized for the pro-oxidant effect of CCl₄. Histopathological studies also supported the protective effect of BBE. CONCLUSION: This study validated the folk and traditional use of snail in liver disorder through CCl₄-induced rat experimental model.
Agid:
461649