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Hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in carbon tetrachloride induced hepatotoxicity in rats

Gomes, Antony, Alam, Mohammed Aftab, Datta, Poulami, Bhattacharya, Shamik, Gomes, Aparna
Journal of ethnopharmacology 2011 v.138 no.1 pp. 228-232
alkaline phosphatase, bilirubin, blood, carbon tetrachloride, hepatoprotective effect, hepatotoxicity, histopathology, liver, markets, medicine, models, oral administration, proteins, rats, snails, superoxide dismutase, triacylglycerols
ETHNOPHARMACOLOGICAL RELEVANCE: In the folk-traditional medicine, snails were used to purify blood, boost immune system, prevent conjunctivitis and to treat liver problems. OBJECTIVES: To evaluate the hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in male Wistar rats treated with carbon tetrachloride as an hepatotoxicant. MATERIALS AND METHODS: Live adult Bellamia bengalensis was collected commercially from the Kolkata market. Aqueous flesh extract (BBE) was prepared in 0.9% saline and expressed in terms of wet weight basis. The aqueous flesh extract was administered orally (1, 2gkg⁻¹day⁻¹) to male rats for 12 days. Liv52 was used as positive control. 24h after administration of extract, the rats were given a single oral dose of CCl₄ (1.25mlkg⁻¹), except vehicle control rats. After 24h of CCl₄ administration, all the animals were sacrificed to collect the blood and liver tissue. RESULTS: BBE (1 and 2gkg⁻¹day⁻¹, p.o.×12 days) significantly prevented CCl₄ induced elevation of SGOT, SGPT, γGT, ACP, ALP, bilirubin, LDH and CCl₄ induced decrease in total protein, triglyceride level in male Wistar rats. BBE treated rat liver anti-oxidant parameters (LPO, SOD, GSH, CAT, GPx) were significantly antagonized for the pro-oxidant effect of CCl₄. Histopathological studies also supported the protective effect of BBE. CONCLUSION: This study validated the folk and traditional use of snail in liver disorder through CCl₄-induced rat experimental model.