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Complete genomic characterization and genetic diversity of four European genotype porcine reproductive and respiratory syndrome virus isolates from China in 2011

Author:
Zhou, Zhi, Liu, Qi, Hu, Dongmei, Zhang, Qian, Han, Tao, Ma, Ying, Gu, Xiaoxue, Zhai, Xinyan, Tian, Kegong
Source:
Virus genes 2015 v.51 no.3 pp. 375-384
ISSN:
0920-8569
Subject:
Porcine reproductive and respiratory syndrome virus, emerging diseases, farms, genetic variation, genotype, monitoring, phylogeny, porcine reproductive and respiratory syndrome, sequence analysis, viruses, China
Abstract:
Porcine reproductive and respiratory syndrome (PRRS) is an emerging disease that has caused serious economic losses to the swine industry worldwide. In 2011, a nation-wide surveillance program investigated the prevalence of PRRS viruses (PRRSV) in Chinese breeding swine farms, and four European genotype PRRSV (PRRSV-Type 1) were successfully isolated. To explore the genetic diversity of PRRSV-Type 1 in China, these 4 viral strains were subjected to genome sequencing and analysis. The four isolates shared 87.4–90.7 % nucleotide homology with the Lelystad strain (PRRSV-Type 1 stereotype strain). NSP2, ORF3, and ORF4 were the most variable regions and contained discontinuous deletions or insertions when compared to other PRRSV-Type 1 strains. All isolates fell into separate branches of the subtype 1 of PRRSV-Type 1 phylogenetic tree. This analysis of emerging PRRSV-Type 1 strains revealed previously unrecorded genetic diversity. Close attention should be paid to the prevention and control of this evolving virus.
Agid:
4663377