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Evaluation of phenotypic factors for anti-rabies antibody in vaccinated pet dogs

Savaliya, Bhumika F., Mathakiya, R. A., Bhanderi, B. B., Jhala, M. K.
VirusDis. 2015 v.26 no.4 pp. 282-287
analysis of variance, antibodies, blood serum, dogs, enzyme-linked immunosorbent assay, humans, immune response, pets, phenotype, rabies, vaccination, vaccines
The aims of this study were to investigate various factors associated with protective anti-rabies antibody status (0.5 EU/ml) in vaccinated pet dogs and anti-rabies antibody status in unvaccinated stray dogs. One hundred and seven serum samples were collected from vaccinated pet dogs, out of these 58 (62.36 %) dogs showed antibody titre above 0.5 EU/ml. All the dogs were divided into different groups based on age, sex, breed, vaccine brand and time of vaccination after last vaccine to assess the relationship of these factors with vaccinal immune response. One way analysis of variance was performed in graphpad prism software to check the effect of all these factors. Statistical analysis of ELISA titres of pet dog serum samples suggested that age, sex, breed and vaccine brands have no significant effect on the anti-rabies antibody titres. To check anti-rabies antibody status in stray dogs 53 serum samples were collected and only one out of 53 (1.88 %) stray dogs showed anti-rabies antibody titre above 0.5 EU/ml indicating susceptibility to rabies infection and thereby posing possible threat to surrounding human and animal populations.