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Ameliorating effect of balloon flower saponin on the ethanol‐induced memory impairment in mice
- Choi, Yeon Hee, Kim, Young Sup, Yeo, Su Jeong, Roh, Seong Hwan, Jeong, Young Chul, Kang, Jong Seong, Ryu, Shi Yong
- Phytotherapy research 2008 v.22 no.7 pp. 973-976
- Platycodon grandiflorum, ethanol, medicinal properties, memory, mice, plant extracts, poisoning, roots, saponins
- The ameliorating effect of the root extract of Platycodon grandiflorum (Campanulaceae) on ethanol‐induced cognitive dysfunction in mice was investigated. The mice with repeated administration of the root extract of P. grandiflorum, crude saponin fraction and platycoside E, a main ingredient of crude saponin fraction, showed a markedly prolonged step‐through latency period (STL) on the passive avoidance task performed after acute ethanol intoxication, respectively. The present results suggest that the memory enhancing effect of the extract was ascribed mainly to the saponin fraction and that saponin of P. grandiflorum, particularly platycoside E could exert a beneficial effect on memory impairment in mice. Copyright © 2008 John Wiley & Sons, Ltd.