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A new labdane diterpene from the rhizomes of Alpinia officinarum

Author:
Zou, Qiong-Yu, Wu, Hai-Feng, Tang, Yu-Lian, Chen, Di-Zhao
Source:
Natural product research 2016 v.30 no.1 pp. 1-6
ISSN:
1478-6427
Subject:
Alpinia officinarum, cytotoxicity, kaempferol, labdane, quercetin, rhizomes, sesquiterpenoids, spectroscopy
Abstract:
A new labdane diterpene, (Z)-12,14-labdadien-15(16)-olide-17-oic acid (1), and a new natural cadinane sesquiterpene, 4-isopropyl-6-methyl-1-naphthalenemethanol (2), were isolated from the ethanolic extract of the rhizomes of Alpinia officinarum , together with three other products, galangin (3), kaempferol (4) and quercetin (5). Their structures were elucidated by using extensive spectroscopic methods. Compounds 1 and 2 showed no remarkable cytotoxic activity against HeLa and HepG2 cancer cell lines with IC ₅₀>50 μg mL ⁻ ¹.
Agid:
4685345