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A novel cyclic dipeptide from deep marine-derived fungus Aspergillus sp. SCSIOW2
- Zhou, Xiang, Fang, Pingyan, Tang, Jianqiang, Wu, Zhiqin, Li, Xiaofan, Li, Shuiming, Wang, Yong, Liu, Gang, He, Zhendan, Gou, Deming, Yao, Xinsheng, Wang, Liyan
- Natural product research 2016 v.30 no.1 pp. 52-57
- Aspergillus, amino acids, cytotoxicity, fungi, inhibitory concentration 50, interferon-gamma, isomers, lipopolysaccharides, mass spectrometry, mice, nitric oxide, nuclear magnetic resonance spectroscopy
- A novel cyclic dipeptide, 14-hydroxy-cyclopeptine (1), was purified from a deep sea derived fungal isolate identified as an Aspergillus sp. The structure was elucidated by detailed spectroscopic analyses using 1D and 2D NMR experiments and high resolution mass spectrometry. The absolute configuration of the amino acid was determined by Marfey's method. Two conformational isomers of 1 were established by ROE analyses. 1 inhibited nitric oxide production with IC ₅₀ values at 40.3 μg/mL in a lipopolysaccharide and recombinant mouse interferon-γ -activated macrophage-like cell line, RAW 264.7 and showed no cytotoxic effect in the tested dose range up to 100 μg/mL.