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Single- versus double-dose rabies vaccination in captive african wild dogs (lycaon pictus)

Connolly, Maren, Thomas, Patrick, Woodroffe, Rosie, Raphael, Bonnie L.
Journal of zoo and wildlife medicine 2015 v.46 no.4 pp. 691-698
Lycaon pictus, Rabies virus, animals, antibodies, blood serum, fluorescence, immune response, neutralization, rabies, vaccination, vaccines
The immune responses of 35 captive African wild dogs (Lycaon pictus) to an inactivated rabies virus vaccine were evaluated. Seventeen animals received one 1-ml dose of inactivated rabies vaccine administered intramuscularly, while 18 received two 1-ml doses given simultaneously but at different injection sites. Sera were collected from all animals prior to vaccination and intermittently from a subset of animals between 3 and 49 mo postvaccination. Rabies neutralizing serum antibody titers were measured by rapid fluorescent focus inhibition testing. Within 3 mo postvaccination, all 28 animals that were tested within that time period had seroconverted. Overall, titers were significantly higher among animals given two doses of vaccine than among those given a single dose, although this difference was no longer significant by 15 mo postvaccination. Regardless of initial dose, a single administration of inactivated rabies virus vaccine resulted in long-term elevation of titers in the African wild dogs in this study. In the two individuals followed for greater than 36 mo, both (one from each group) maintained detectable titers.