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Single- versus double-dose rabies vaccination in captive african wild dogs (lycaon pictus)
- Connolly, Maren, Thomas, Patrick, Woodroffe, Rosie, Raphael, Bonnie L.
- Journal of zoo and wildlife medicine 2015 v.46 no.4 pp. 691-698
- Lycaon pictus, Rabies virus, animals, antibodies, blood serum, fluorescence, immune response, neutralization, rabies, vaccination, vaccines
- The immune responses of 35 captive African wild dogs (Lycaon pictus) to an inactivated rabies virus vaccine were evaluated. Seventeen animals received one 1-ml dose of inactivated rabies vaccine administered intramuscularly, while 18 received two 1-ml doses given simultaneously but at different injection sites. Sera were collected from all animals prior to vaccination and intermittently from a subset of animals between 3 and 49 mo postvaccination. Rabies neutralizing serum antibody titers were measured by rapid fluorescent focus inhibition testing. Within 3 mo postvaccination, all 28 animals that were tested within that time period had seroconverted. Overall, titers were significantly higher among animals given two doses of vaccine than among those given a single dose, although this difference was no longer significant by 15 mo postvaccination. Regardless of initial dose, a single administration of inactivated rabies virus vaccine resulted in long-term elevation of titers in the African wild dogs in this study. In the two individuals followed for greater than 36 mo, both (one from each group) maintained detectable titers.