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A Strategy to Employ Clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression

Author:
Margret, A. Anita, Begum, T. Nargis, Parthasarathy, S., Suvaithenamudhan, S.
Source:
Nat. Prod. Bioprospect. 2015 v.5 no.6 pp. 293-306
ISSN:
2192-2195
Subject:
Ayurvedic medicine, Clitoria ternatea, amine oxidase (flavin-containing), amino acids, binding capacity, brain, drugs, energy, gas chromatography-mass spectrometry, medicinal plants, molecular models, neurodegenerative diseases, phytopharmaceuticals, India
Abstract:
Ayurveda is a renowned traditional medicine practiced in India from ancient times and Clitoria ternatea is one such prospective medicinal herb incorporated as an essential constituent in a brain tonic called as medhya rasayan for treating neurological disorders. This work emphasises the significance of the plant as a brain drug there by upholding Indian medicine. The phytochemicals from the root extract were extricated using gas chromatography–mass spectrometry assay and molecular docking against the protein Monoamine oxidase was performed with four potential compounds along with four reference compounds of the plant. This persuades the prospect of C. ternatea as a remedy for neurodegenerative diseases and depression. The in silico assay enumerates that a major compound (Z)-9,17-octadecadienal obtained from the chromatogram with a elevated retention time of 32.99 furnished a minimum binding affinity energy value of −6.5 kcal/mol against monoamine oxidase (MAO-A). The interactions with the amino acid residues ALA 68, TYR 60 and TYR 69 were analogous to the reference compound kaempferol-3-monoglucoside with a least score of −13.90/−12.95 kcal/mol against the isoforms (MAO) A and B. This study fortifies the phytocompounds of C. ternatea as MAO-inhibitors and to acquire a pharmaceutical approach in rejuvenating Ayurvedic medicine.
Agid:
4689827