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Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)

Author:
Tomosaka, Hideyuki, Chin, Young‐Won, Salim, Angela A., Keller, William J., Chai, Heebyung, Kinghorn, A. Douglas
Source:
Phytotherapy research 2008 v.22 no.7 pp. 979-981
ISSN:
0951-418X
Subject:
Berberis vulgaris, antioxidant activity, antioxidants, bark, bioassays, cultured cells, fractionation, hydrogen peroxide, phenolic compounds, roots, tyramine
Abstract:
Activity‐guided fractionation of an EtOAc‐soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical‐scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N‐(p‐trans‐coumaroyl)tyramine, cannabisin G and (±)‐lyoniresinol. Of these, cannabisin G and (±)‐lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF‐7 cells modulated by hydrogen peroxide. Copyright © 2008 John Wiley & Sons, Ltd.
Agid:
472896