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New cytotoxic spongian-class rearranged diterpenes from a marine sponge
- Uddin, Mohammad Helal, Hossain, Mohammed Kamrul, Nigar, Meher, Roy, Michael Chandro, Tanaka, Junichi
- Chemistry of natural compounds 2012 v.48 no.3 pp. 412-415
- bladder, carbon, chemical analysis, cytotoxicity, diterpenoids, epithelial cells, rats
- Chemical investigation of an Okinawan marine sponge resulted in the isolation of two new spongian-class diterpenes 1 and 2 together with two known compounds, chromodorolide B (3) and chromodorolide C (4). Compound 1, named chromodorolide D, is an example of a diterpenoid with a highly rearranged chromodorane carbon skeleton, while compound 2 retains the open side chains. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and chemical conversion. Compounds 1–4 exhibited significant cytotoxicity against NBT-T2 rat bladder epithelial cells.