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Acute and Sub-acute Oral Toxicity of Hydroethanolic Root Extract of Annona stenophylla Engl. and Diels in Sprague Dawley Rats

Chagonda, Lameck S., Tafadzwa, Munodawafa, Dexter, Tagwirei, Louis, Gadaga, Exnevia, Gomo, Felicity, Bierman, Tapiwa, Siziba
Journal of Biologically Active Products from Nature 2015 v.5 no.5 pp. 349-356
Annona, acute toxicity, alanine transaminase, alkaline phosphatase, aspartate transaminase, behavior change, bilirubin, body weight, creatinine, gamma-glutamyltransferase, glucose, histopathology, liver, pancreas, rats, toxicity testing
The acute and sub-acute oral toxicity of the hydroethanolic root extract of Annona stenophylla Engl. and Diels in Sprague Dawley rats was determined by administering the crude extract daily in the range 250–2000 mg/kg body weight and the animals examined for physical, histopathological and clinical biochemistry changes. There were no behavioural changes or deaths in the acute toxicity tests up to 2000 mg/kg b. wt over 14 days. There were no major changes in the clinical biochemistry parameters measured: Alanine aminotransferase (ALT), Aspartate amino transferase (AST), Alkaline phosphatase (ALP), Gamma-glutamyl transferase (GGT), glucose, creatinine and total bilirubin (p>0.05) and in the histopathological tissue sections of the pancreas and liver compared with the control rats in the sub-acute tests over 28 days. The present report supports the traditional medicinal use and relative safety of A. stenophylla in the treatment of multiple ailments including its antidiabetic potential.