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Antiinflammatory properties of Morus nigra leaves

Author:
Padilha, Marina M., Vilela, Fabiana C., Rocha, Cláudia Q., Dias, Marcelo J., Soncini, Roseli, dos Santos, Marcelo H., Alves-da-Silva, Geraldo, Giusti-Paiva, Alexandre
Source:
Phytotherapy research 2010 v.24 no.10 pp. 1496-1500
ISSN:
0951-418X
Subject:
Morus nigra, acids, animal models, anti-inflammatory activity, cotton, edema, high performance liquid chromatography, leaves, methylene chloride, pellets, rats
Abstract:
The aim of the present study was to investigate antiinflammatory activity of the methylene chloride extract of Morus nigra in animal models. Carrageenan-induced paw edema as well as fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the antiinflammatory activity of Morus nigra extract (MnE) in rats. A HPLC fingerprint was used for phytochemical analysis of the extracts. The MnE at test doses of 100-300 mg/kg p.o. clearly demonstrated antiinflammatory effects by reduced paw edema induced by carragenan and significantly inhibited the formation of granulomatous tissue. In addition, chemical compounds isolated from Morus nigra, including betulinic acid, β-sitosterol and germanicol, may be responsible for the antiinflammatory effect of the extract.
Agid:
474648