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Hepatic biotransformation profiles of sulphamonomethoxine in food-producing animals and rats in vitro

Author:
Furusawa, N.
Source:
Acta veterinaria Hungarica 2000 v.48 no.3 pp. 293-300
ISSN:
0236-6290
Subject:
acetylation, biotransformation, cows, food animals, hydroxylation, laying hens, liver, rats, swine
Abstract:
Hydroxylation and acetylation of sulphamonomethoxine (SMM) and deacetylation of N4-acetyl SMM (N4-AcSMM) were estimated in liver post-mitochondrial supernatants (S-9) from laying hens, female cattle, swine and rats. The formation of hydroxylated SMM, 2,6-dihydroxy SMM (2,6-diOH-SMM), was found only with hen S-9s. N4-acetylation rate of SMM was the highest in pig S-9s, followed by rat, then hen or cow S-9s. All S-9s from the four species deacetylated N4-AcSMM. In hen S-9s, the rate of 2,6-dihydroxylation was higher during incubation at 41 °C than at 37 °C.
Agid:
4796280