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Assessment of the cardiotoxicity of tulathromycin in rabbits

Er, Ayse, Altan, Feray, Cetin, Gul, Dik, Burak, Elmas, Muammer, Yazar, Enver
Acta veterinaria Hungarica 2011 v.59 no.3 pp. 327-335
adults, alanine transaminase, albumins, alkaline phosphatase, aspartate transaminase, beta-carotene, bicarbonates, blood gases, blood sampling, blood serum, calcium, carbon dioxide, cholesterol, creatine, creatinine, drugs, erythrocytes, gamma-glutamyltransferase, glucose, hematocrit, hemoglobin, high density lipoprotein, lactate dehydrogenase, leukocyte count, leukocytes, macrolide antibiotics, males, malondialdehyde, myoglobin, nitric oxide, oxygen, pH, potassium, protein content, rabbits, sodium, superoxide dismutase, triacylglycerols, troponin I, urea nitrogen, veterinary medicine, vitamin A
The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess <i>in vivo</i>, base excess <i>in vitro</i>, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.