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Antioxidant Properties of <i>Myrtilli Folium</i>, <i>Phaseoli Fructus Sine Seminibus </i>and Drug Mixture Extracts

Author:
Then, M., Szentmihályi, K., Gere, A., Jasztrab, Sz., Szőke, É.
Source:
Acta alimentaria 2005 v.34 no.2 pp. 169-176
ISSN:
0139-3006
Subject:
2,2-diphenyl-1-picrylhydrazyl, NADP (coenzyme), antioxidant activity, brain, drugs, free radical scavengers, hydroxyl radicals, iron, lipid peroxidation, microsomes, superoxide anion, tetrazolium
Abstract:
In vitro investigations for the antioxidant and free radical scavenging activity of <i>Myrtilli folium-, Phaseoli fructus sine seminibus-</i> and a drug mixture (<i>Equiseti herba, Myrtilli folium, Phaseoli fructus sine seminibus, Urticae folium</i>) extracts showed antioxidant (LPO inhibitory and chain-breaking antioxidant) activity and free radical (superoxide anion and hydroxyl radical) scavenging effect. The extracts inhibited lipid peroxidation induced enzymatically by adding NADPH and non-enzymatically by adding Fe<sup>2+</sup> in brain microsomes and in brain homogenates, respectively. The extracts reduced the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), which showed chain-breaking antioxidant activity. The extracts scavenged superoxide radicals (O<sub>2</sub>-·) by inhibiting the reduction of nitro blue tetrazolium evoked by phenazine methosulphate. In addition, the extracts inhibited Fenton-reagent (Fe<sup>2+ </sup>and H<sub>2</sub>O<sub>2</sub>) induced deoxyribose degradation, therefore, it was concluded that the extracts have hydroxyl radical (OH·) scavenging property.
Agid:
4797539