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Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus xanthus
- Stevens, D. Cole, Henry, Michael R., Murphy, Kimberly A., Boddy, Christopher N.
- Applied and environmental microbiology 2010 v.76 no.8 pp. 2681-2683
- Myxococcus xanthus, biochemical pathways, genomic libraries, hosts, multigene family, new products, oxytetracycline
- New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.