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A comparison of propofol infusion and propofol/isoflurane anaesthesia in dexmedetomidine premedicated dogs

Kuusela, E., Vainio, O., Short, C.E., Leppaluoto, J., Huttunen, P., Strom, S., Huju, V., Valtonen, A., Raekallio, M.
Journal of veterinary pharmacology and therapeutics 2003 v.26 no.3 pp. 199-204
Beagle, anesthesia, blood, dexmedetomidine, dogs, epinephrine, gases, heart rate, isoflurane, stress response
The effects of propofol infusion were compared with propofol/isoflurane anaesthesia in six beagles premedicated with 10 μg/kg intramuscular (i.m.) dexmedetomidine. The suitability of a cold pressor test (CPT) as a stress stimulus in dogs was also studied. Each dog received isoflurane (end tidal 1.0%, induction with propofol) with and without CPT; propofol (200 μg/kg/min, induction with propofol) with and without CPT; premedication alone with and without CPT in a randomized block study in six separate sessions. Heart rate and arterial blood pressures and gases were monitored. Plasma catecholamine, beta-endorphin and cortisol concentrations were measured. Recovery profile was observed. Blood pressures stayed within normal reference range but the dogs were bradycardic (mean heart rate < 70 bpm). PaCO2 concentration during anaesthesia was higher in the propofol group (mean > 57 mmHg) when compared with isoflurane (mean < 52 mmHg). Recovery times were longer with propofol than when compared with the other treatments. The mean extubation times were 8 ± 3.4 and 23 ± 6.3 min after propofol/isoflurane and propofol anaesthesia, respectively. The endocrine stress response was similar in all treatments except for lower adrenaline level after propofol infusion at the end of the recovery period. Cold pressor test produced variable responses and was not a reliable stress stimulus in the present study. Propofol/isoflurane anaesthesia was considered more useful than propofol infusion because of milder degree of respiratory depression and faster recovery.