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Galanin - Immunoreactive Nerve Fibers in the Mucosal Layer of the Canine Gastrointestinal Tract During Inflammatory Bowel Disease

Author:
Rychlik, Andrzej, Gonkowski, Sławomir, Nowicki, Marcin, Całka, Jarosław, Szweda, Marta
Source:
Bulletin of the Veterinary Institute in Puławy = 2015 v.59 no.1 pp. 143-148
Subject:
biopsy, colon, disease severity, dogs, duodenum, fluorescent antibody technique, inflammatory bowel disease, jejunum, mucosa, nerve fibers, pathogenesis, patients
Abstract:
The effect of inflammatory bowel disease (IBD) on the density of galanin - immunoreactive (GAL-IR) nerve fibers was determined in the mucosa of canine duodenum, jejunum, and descending colon. Fiber density was evaluated by a single immunofluorescence method in biopsy specimens obtained from healthy dogs and patients with variable severity of the disease. The density of GAL-IR nerve fibers was determined by the semi-quantitative method by counting fibers in the field of view (0.l mm²). Fiber density was higher in dogs with moderate and severe IBD than in healthy animals. The results of the study suggest that GAL present in intestinal nerve fibers could play a role in the pathogenesis and development of canine IBD.
Agid:
4808921