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Keith's MAGIC: Cloning and the Cell Cycle
- Wells, D.N.
- Cellular reprogramming 2013 v.15 no.5 pp. 348-355
- adults, animals, cell cycle, cloning (cells), oocytes, somatic cells, totipotency
- Professor Keith Campbell's critical contribution to the discovery that a somatic cell from an adult animal can be fully reprogrammed by oocyte factors to form a cloned individual following nuclear transfer (NT)(Wilmut et al., 1997) overturned a dogma concerning the reversibility of cell fate that many scientists had considered to be biologically impossible. This seminal experiment proved the totipotency of adult somatic nuclei and finally confirmed that adult cells could differentiate without irreversible changes to the genetic material.