PubAg

Main content area

Association study of protamine 2 (PRM2) gene polymorphism with male infertility in Chinese Han population

Author:
Yang, Xuemei, Liu, Fang, Li, Jun, Song, Yaman, Tan, Yuzhe
Source:
Genes & genomics 2016 v.38 no.3 pp. 311-317
ISSN:
1976-9571
Subject:
Chinese people, DNA, alleles, genetic variation, genotype, loci, male fertility, men, pathogenesis, risk, semen, single nucleotide polymorphism, sperm motility, spermatogenesis, spermatozoa, statistical analysis
Abstract:
Protamine 2 (PRM2), an essential nuclear protein expressed in sperm, is known to be involved in the spermatogenesis. Although PRM2 defects have been reported to be involved in male infertility, studies for the relationship between male infertility and PRM2 polymorphisms are inconclusive. With the purpose to determine the association of PRM2 variant with male infertility in Chinese Han population, one single nucleotide polymorphism locus G398C in PRM2 which might play a role in semen quality was selected and the variant frequency was analyzed in 144 idiopathic infertile men (case group) and 111 proven-fertile men (control group) in the study. Three genotypes were discovered in the studied population and statistical analysis showed that the frequencies of GG and GC genotypes of PRM2 G398C were significantly different between the fertile and infertile men (P < 0.05) and GC genotype was associated with increased risk of male infertility (OR = 1.795, 95 % CI 1.070–3.013, P = 0.026). Further, the C allele distribution was significantly elevated in infertile group (OR = 1.484, 95 % CI 1.001–2.200, P = 0.049). Moreover, we discovered that sperm motility, progressive motility, sperm DNA integrity as well as nuclear maturity rate of GG genotype presented the highest values and were dramatically different with that of CC genotype (P < 0.05). Our results gave the first evidence that PRM2 G398C polymorphism was associated with the pathogenesis of male infertility and its genetic variation was in relation to semen quality in Chinese Han population.
Agid:
5013235