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Expression of nectin-4 as a potential biomarker in enzootic nasal adenocarcinoma of goats

Author:
Aydoğan, Ahmet, Özmen, Özlem
Source:
Acta veterinaria Hungarica 2016 v.64 no.1 pp. 71-77
ISSN:
1588-2705
Subject:
Capra hircus, adenocarcinoma, biomarkers, females, goats, immunohistochemistry, males, microscopy, nose, tissues
Abstract:
The aim of this study was to test nectin-4 by immunohistochemistry as a potential biomarker in enzootic nasal adenocarcinoma (ENA) of goats. Twentyfour archival ENA case samples [from 14 male and 10 female hair goats (Capra hircus) ] were used. The samples were stained with haematoxylin and eosin (HE). Nectin-4 expression was studied by immunohistochemistry. By microscopy, tubular, papillary, and mixed patterns of ENA were diagnosed in the cases. Immunohistochemically, the tumours showed moderate nectin-4 expression (++) in 14 cases (58.3%), strong expression (+++) in five cases (20.8%), and weak expression (+) in three cases (12.5%), while two cases (8.3%) were negative. Normal nasal tissues were not stained with nectin-4. The results suggest that nectin-4 may be used as a valuable biomarker of ENA.
Agid:
5125465