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Humic Acid and Glucan: Protection Against Liver Injury Induced by Carbon Tetrachloride
- Vetvicka, Vaclav, Garcia-Mina, Jose M., Proctor, Mary, Yvin, Jean-Claude
- Journal of medicinal food 2015 v.18 no.5 pp. 572-577
- beta-glucans, carbon tetrachloride, hepatoprotective effect, hepatotoxicity, humic acids, liver, models
- Humic acids (HAs) have a rather pleiotropic presence, however, their biological effects are still unclear. In this study, we focused on possible hepatoprotective effects of either HA alone or in combination with β-glucan. Using a model of experimental hepatotoxicity caused by carbon tetrachloride (CCL₄), we showed that both HA and the glucan-HA combination offered significant protection against hepatotoxicity, with the combination offering superior effects. Our biochemical observations were confirmed by histological evaluation. Based on the experimental data, we conclude that whereas HA has significant effects, the synergy with glucan offers superior effects.