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Preventive Effect of Monascus-Fermented Products Enriched with Ubiquinones on Type 2 Diabetic Rats Induced by a High-Fructose Plus High-Fat Diet

Pyo, Young-Hee, Lee, Kyung-Won
Journal of medicinal food 2014 v.17 no.7 pp. 826-829
animal disease models, antioxidants, catalase, dietary supplements, glucose, glucose tolerance, glutathione peroxidase, glycemic effect, grains, high fat diet, hyperglycemia, hyperinsulinemia, insulin resistance, lipid peroxidation, males, noninsulin-dependent diabetes mellitus, oral administration, oxidative stress, rats, superoxide dismutase, ubiquinones
The aim of the present study was to investigate whether the aqueous extract of Monascus-fermented grains (MFGEs) enriched with ubiquinones (Coenzyme Qs, CoQ₉+CoQ₁₀) alleviates high-fructose (60%) plus high-fat (20%) diet (HFD)-induced hyperglycemia and hepatic oxidative stress in male Sprague–Dawley rats. Animals were fed HFD for 16 weeks and orally administered with MFGEs (300 mg/kg/day) or atorvastatin (20 mg/kg/day) for the last 4 weeks of the study. HFD-fed rats exhibited hyperglycemia, hyperinsulinemia, impaired glucose tolerance, and impaired insulin sensitivity. MFGE treatment prevented the increase in glucose levels and index of insulin resistance in the HFD-induced diabetic rats. A significant decrease in hepatic lipid peroxidation and significant increases in hepatic superoxide dismutase, catalase, and glutathione peroxidase were observed in the MFGE supplemented group. The results suggest that dietary supplementation with MFGEs enriched with CoQs exerts an antidiabetic effect in type 2 diabetic rats by improving insulin resistance and hepatic antioxidant enzymes.