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Screening of Phenolic Compounds Reveals Inhibitory Activity of Nordihydroguaiaretic Acid Against Three Enzymes Involved in the Regulation of Blood Glucose Level

Author:
Roškar, Irena, Štrukelj, Borut, Lunder, Mojca
Source:
Plant foods for human nutrition 2016 v.71 no.1 pp. 88-89
ISSN:
0921-9668
Subject:
Larrea tridentata, alpha-amylase, alpha-glucosidase, blood glucose, diabetes, glucose, inhibitory concentration 50, mechanism of action, nordihydroguaiaretic acid, screening
Abstract:
In this work we have focused on the inhibition of three different enzymes with a role in postprandial glucose management: α-amylase, α-glucosidase and dipeptidyl peptidase 4. The assortment of 29 monomeric phenolic compounds was first screened at a single concentration. Next, the IC₅₀ values of tested compounds were evaluated for compounds that considerably inhibited any of the enzymes. Nordihydroguaiaretic acid, a phenolic compound abundant in Creosote bush Larrea tridentata, possessed inhibitory activity for all tested enzymes. This in vitro mechanism of action supports traditional use of Creosote bush in diabetes treatment.
Agid:
5152348