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Screening of Phenolic Compounds Reveals Inhibitory Activity of Nordihydroguaiaretic Acid Against Three Enzymes Involved in the Regulation of Blood Glucose Level
- Roškar, Irena, Štrukelj, Borut, Lunder, Mojca
- Plant foods for human nutrition 2016 v.71 no.1 pp. 88-89
- Larrea tridentata, alpha-amylase, alpha-glucosidase, blood glucose, diabetes, glucose, inhibitory concentration 50, mechanism of action, nordihydroguaiaretic acid, screening
- In this work we have focused on the inhibition of three different enzymes with a role in postprandial glucose management: α-amylase, α-glucosidase and dipeptidyl peptidase 4. The assortment of 29 monomeric phenolic compounds was first screened at a single concentration. Next, the IC₅₀ values of tested compounds were evaluated for compounds that considerably inhibited any of the enzymes. Nordihydroguaiaretic acid, a phenolic compound abundant in Creosote bush Larrea tridentata, possessed inhibitory activity for all tested enzymes. This in vitro mechanism of action supports traditional use of Creosote bush in diabetes treatment.