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Short Communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

Author:
Manunza, A., Zidi, A., Fernández-Cabanás, V. M., Jordana, J., Carrizosa, J., Belaifa, E., Urrutia, B., Polvillo, O., González-Redondo, P., Amills, M., Serradilla, J. M.
Source:
Canadian journal of plant science 2012 v.92 no.2 pp. 167-173
ISSN:
1918-1833
Subject:
3' untranslated regions, Murcia-Granada, biosynthesis, cholesterol, fatty acid composition, gene expression, genes, genotype, goats, leucine, milk, milk analysis, milk fat, milk yield, omega-3 fatty acids, proline, transcription factors
Abstract:
Manunza, A., Zidi, A., Fernández-Cabanás, V. M., Jordana, J., Carrizosa, J., Belaifa, E., Urrutia, B., Polvillo, O., González-Redondo, P., Amills, M. and Serradilla, J. M. 2012. Short Communication: An association analysis between one missense polymorphism at theSREBF1gene and milk yield and composition traits in goats. Can. J. Anim. Sci. 92: 167–173. Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3′UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C>T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano-Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.
Agid:
5154945