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Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction

Author:
Gorojankina, Tatiana
Source:
Cellular and molecular life sciences 2016 v.73 no.7 pp. 1317-1332
ISSN:
1420-682X
Subject:
G-protein coupled receptors, cAMP-dependent protein kinase, cell proliferation, cilia, models, signal transduction, stem cells, transcription factors, vertebrates
Abstract:
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning and stem cell maintenance. In spite of intensive study, the mechanisms of Hh signal transduction are not completely understood. Here I review published data and present a novel model of vertebrate Hh signaling suggesting that Smoothened (Smo) functions as a G-protein-coupled receptor in cilia. This is the first model to propose molecular mechanisms for the major steps of Hh signaling, including inhibition of Smo by Patched, Smo activation, and signal transduction from active Smo to Gli transcription factors. It also suggests a novel role for the negative pathway regulators Sufu and PKA in these processes.
Agid:
5158326