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Biochemical and histopathological evaluation of changes in sled dog paw skin associated with physical stress and cold temperatures
- BRADLEY, DINO M., SWAIM, STEVEN F., VAUGHN, DANA M., POWERS, ROBERT D., MCGUIRE, JOHN A., REINHART, GREGORY A., BURR, JOHN, SWENSON, RICK A.
- Veterinary dermatology 1996 v.7 no.4 pp. 203-208
- ambient temperature, biopsy, cold, cold stress, dogs, histopathology, snow, Alaska
- Abstract Twenty‐six Alaskan sled dogs were used to study the biochemical and histopathological changes which occur when dog paws are exposed to cold temperatures and physical stress. They were separated into a running group of 20 dogs and a control group of six non‐running dogs. Over 2 1/2 days, the running group ran in their natural environment for 170 miles and environmental parameters were recorded. Following the run, an 8‐mm díameter skin biopsy specimen was taken from the lateral aspect of the right fore and hind paws of the running and non‐running dogs. The skin was evaluated for histopathological changes and the présence of 2, 3‐dinor thromboxane B2 (2, 3‐dinor TxB2). No significant histopathological changes were noted in any of the biopsy specimens. Based on measured elevation of 2, 3‐dinor TxB2, the forepaws experienced more physical stress than the hind paws. Wet snow at higher environmental temperatures caused more paw stress than hard crusted snow at lower environmental temperatures.