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Novel inhibitors of the Plasmodium falciparum electron transport chain

Author:
STOCKS, P. A., BARTON, V., ANTOINE, T., BIAGINI, G. A., WARD, S. A., O'NEILL, P. M., Barrett, Michael P., Croft, Simon L.
Source:
Parasitology 2014 v.141 no.1 pp. 50-65
ISSN:
1469-8161
Subject:
NAD (coenzyme), Plasmodium falciparum, antimalarials, drug resistance, electron transport chain, evolution, parasites, researchers
Abstract:
Due to an increased need for new antimalarial chemotherapies that show potency against Plasmodium falciparum, researchers are targeting new processes within the parasite in an effort to circumvent or delay the onset of drug resistance. One such promising area for antimalarial drug development has been the parasite mitochondrial electron transport chain (ETC). Efforts have been focused on targeting key processes along the parasite ETC specifically the dihydroorotate dehydrogenase (DHOD) enzyme, the cytochrome bc₁ enzyme and the NADH type II oxidoreductase (PfNDH2) pathway. This review summarizes the most recent efforts in antimalarial drug development reported in the literature and describes the evolution of these compounds.
Agid:
5172587