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Influence of acetylcysteine on cytogenetic effects of etoposide in mouse oocytes

Author:
Pligina, K. L., Zhanataev, A. K., Kulakova, A. V., Chaika, Z. V., Durnev, A. D.
Source:
Russian journal of genetics 2016 v.52 no.2 pp. 188-193
ISSN:
1022-7954
Subject:
acetylcysteine, cytogenetics, dose response, etoposide, females, mice, oocytes
Abstract:
The influence of N-acetylcysteine (ACC) on the cytogenetic effects of etoposide in F₁ CBA × C57BL/6 mice was studied. Etoposide introduced intraperitoneally in doses of 10, 20, 40, and 60 mg/kg has a dose-dependent clastogenic activity and has an aneugenic effect with the induction of mainly hypohaploid oocytes. ACC significantly decreases the aneugenic and clastogenic activity of etoposide (20 mg/kg) in oocytes of 6-, 9-, and 12-week-old mice during triple introduction at a dose 200 mg/kg per os. The most pronounced anticlastogenic ACC activity (an 80% decrease) was registered in 9-week-old females; a 100% decrease in aneugenesis was detected in 6-week-old female mice.
Agid:
5177562