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Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

Author:
Lobo, Bianca W, da Veiga, Venício F, Cabral, Lúcio M, Michel, Ricardo C, Volpato, Nádia M, de Sousa, Valéria P
Source:
Nutrition journal 2012 v.11 no.1 pp. 494
ISSN:
1475-2891
Subject:
color, light scattering, microscopy, osmolarity, pH, peroxides, storage temperature, total parenteral nutrition, trace elements, vitamins
Abstract:
OBJECTIVE: The present study aimed to evaluate the influence of the relative composition of trace elements and vitamins in physicochemical stability of neonatal parenteral nutrition. MATERIAL AND METHODS: Three formulations for neonatal administration were selected; the main variable was the presence of trace elements and vitamins. The analyses where carried out immediately after preparation and at 24 h, 48 h, 72 h and 7 days after preparation. Three methods were selected to determine globule size: light obscuration, dynamic light scattering and optical microscopy. Complementary evaluation including visual inspection, determination of pH and osmolarity, peroxide levels and measurements of zeta potential were also performed. RESULTS: There was an observable alteration in color and phase separation in the PN stored at 25°C and 40°C. Neither globule size pattern, nor any other physicochemical characteristic evaluated appeared to be considerably altered in any of the analyzed formulations even after 7 days of storage at 5°C. Globule size in all the PN studied was consistent with the established limit, below 500 nm by DLS measurement, and PFAT₅ was below 0.05% under all storage temperatures. CONCLUSION: Concomitant presence of trace elements and vitamins in the same neonatal formulation did not alter the evaluated aspects of stability.
Agid:
518952