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Larvicidal and Acetylcholinesterase Inhibitory Activities of Apiaceae Plant Essential Oils and Their Constituents against Aedes albopictus and Formulation Development

Author:
Seo, Sion-Mi, Jung, Chan-Sik, Kang, Jaesoon, Lee, Hyo-Rim, Kim, Sung-Woong, Hyun, Jinho, Park, ll-Kwon
Source:
Journal of agricultural and food chemistry 2015 v.63 no.45 pp. 9977-9986
ISSN:
0021-8561
Subject:
Aedes albopictus, Anethum graveolens, Apium graveolens, Carum carvi, Cuminum cyminum, Daucus carota, Petroselinum crispum, Trachyspermum ammi, acetylcholinesterase, alpha-phellandrene, alpha-pinene, beta-pinene, caraway, carrots, carvacrol, celery, cineole, cumin, dill, essential oils, gamma-terpinene, inhibitory concentration 50, larvae, larvicides, mortality, neral, oils, p-cymene, parsley, polyvinyl alcohol, thymol
Abstract:
This study evaluated the larvicidal activity of 12 Apiaceae plant essential oils and their components against the Asian tiger mosquito, Aedes albopictus, and the inhibition of acetylcholine esterase with their components. Of the 12 plant essential oils tested, ajowan (Trachyspermum ammi), caraway seed (Carum carvi), carrot seed (Daucus carota), celery (Apium graveolens), cumin (Cuminum cyminum), dill (Anethum graveolens), and parsley (Petroselinum sativum) resulted in >90% larval mortality when used at 0.1 mg/mL. Of the compounds identified, α-phellandrene, α-terpinene, p-cymene, (−)-limonene, (+)-limonene, γ-terpinene, cuminaldehyde, neral, (S)-+-carvone, trans-anethole, thymol, carvacrol, myristicin, apiol, and carotol resulted in >80% larval mortality when used at 0.1 mg/mL. Two days after treatment, 24.69, 3.64, and 12.43% of the original amounts of the celery, cumin, and parsley oils, respectively, remained in the water. Less than 50% of the original amounts of α-phellandrene, 1,8-cineole, terpinen-4-ol, cuminaldehyde, and trans-antheole were detected in the water at 2 days after treatment. Carvacrol, α-pinene, and β-pinene inhibited the activity of Ae. albopictus acetylcholinesterase with IC50 values of 0.057, 0.062, and 0.190 mg/mL, respectively. A spherical microemulsion of parsley essential oil-loaded poly(vinyl alcohol) (PVA) was prepared, and the larvicidal activity of this formulation was shown to be similar to that of parsley oil.
Agid:
5194349