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Field‐enhanced sample injection micelle‐to‐solvent stacking capillary zone electrophoresis–electrospray ionization mass spectrometry of antibiotics in seawater after solid‐phase extraction

Author:
Wuethrich, Alain, Haddad, Paul R., Quirino, Joselito P.
Source:
Electrophoresis 2016 v.37 no.9 pp. 1139-1142
ISSN:
0173-0835
Subject:
electrophoresis, ionization, mass spectrometry, penicillins, seawater, solid phase extraction, sulfonamides
Abstract:
The synergistic stacking approach of field‐enhanced sample injection‐micelle‐to‐solvent stacking was used for high sensitivity CZE‐ESI‐MS of eight penicillins and sulfonamides. Sensitivity enhancement factors (peak height) were 1629–3328 compared to typical injection, with LODs from 0.11 to 0.55 ng/mL. The analytical figures of merit were acceptable. SPE on a fortified seawater sample resulted in 50‐fold enrichment with recoveries of 85–110%. The overall method LODs were 0.002–0.011 ng/mL.
Agid:
5195383