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Genomic, pathogenic, and antigenic comparisons of Getah virus strains isolated in 1978 and 2014 in Japan

Author:
Nemoto, Manabu, Bannai, Hiroshi, Tsujimura, Koji, Yamanaka, Takashi, Kondo, Takashi
Source:
Archives of virology 2016 v.161 no.6 pp. 1691-1695
ISSN:
0304-8608
Subject:
Getah virus, amino acid sequences, amino acid substitution, antiserum, nucleotide sequences, racehorses, sequence analysis, structural proteins, vaccines, viral nonstructural proteins, Japan
Abstract:
A Getah virus strain isolated during an outbreak in racehorses in Japan in 2014 (14-I-605) was compared with the vaccine strain isolated in 1978 (MI-110). A comparison of the genome sequences of these strains revealed seven amino acid substitutions in non-structural protein 3, and one or two substitutions in each of other non-structural proteins. In contrast, the structural proteins were highly conserved (99.8–99.9 % amino acid sequence identity). Horse antisera raised against the MI-110 strain showed similar virus-neutralization titers against both MI-110 and 14-I-605 strains (512 and 256, respectively). Therefore, antigenic mutation was probably not a direct cause of the outbreak that occurred in 2014.
Agid:
5203165