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Characterization of a Novel Lytic Protein Encoded by the Bacillus cereus E33L Gene ampD as a Bacillus anthracis Antimicrobial Protein

Author:
Bourguet, Feliza A., Souza, Brian E., Hinz, Angela K., Coleman, Matthew A., Jackson, Paul J.
Source:
Applied and environmental microbiology 2012 v.78 no.8 pp. 3025-3027
ISSN:
0099-2240
Subject:
Bacillus anthracis, Bacillus cereus, amidase, antimicrobial proteins, bacterial proteins, biosynthesis, cell walls, genes
Abstract:
Lytic proteins encoded by bacterial genomes have been implicated in cell wall biosynthesis and recycling. The Bacillus cereus E33L ampD gene encodes a putative N-acetylmuramoyl-L-alanine amidase. This gene, expressed in vitro, produced a very stable, highly active lytic protein. Very low concentrations rapidly and efficiently lyse vegetative Bacillus anthracis cells.
Agid:
520515