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Influence of Mycotoxin Binders on the Oral Bioavailability of Doxycycline in Pigs

Author:
Mil, Thomas de, Devreese, Mathias, Saeger, Sarah de, Eeckhout, Mia, Backer, Patrick de, Croubels, Siska
Source:
Journal of agricultural and food chemistry 2016 v.64 no.10 pp. 2120-2126
ISSN:
0021-8561
Subject:
absorption, bioavailability, doxycycline, drinking water, drugs, feed additives, gastrointestinal system, mycotoxins, oral administration, swine
Abstract:
Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the gastrointestinal tract of animals, making them unavailable for systemic absorption. The antimicrobial drug doxycycline (DOX) is often used in pigs and is administered through feed or drinking water; hence, DOX can come in contact with mycotoxin binders in the gastrointestinal tract. This paper describes the effect of four mycotoxin binders on the absorption of orally administered DOX in pigs. Two experiments were conducted: The first used a setup with bolus administration to fasted pigs at two different dosages of mycotoxin binder. In the second experiment, DOX and the binders were mixed in the feed at dosages recommended by the manufacturers (= field conditions). Interactions are possible between some of the mycotoxin binders dosed at 10 g/kg feed but not at 2 g/kg feed. When applying field conditions, no influences were seen on the plasma concentrations of DOX.
Agid:
5209495