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Mechanisms and consequences of entosis
- Krishna, Shefali, Overholtzer, Michael
- Cellular and molecular life sciences 2016 v.73 no.11-12 pp. 2379-2386
- carcinogenesis, cell death, hosts
- Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called ‘cell-in-cell’ structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.