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Black Rice with Giant Embryo Attenuates Obesity-Associated Metabolic Disorders in ob/ob Mice
- Lee, Yoon-Mi, Han, Sank-Ik, Won, Yu-Jin, Lee, Eunji, Park, Eunju, Hwang, Seock-Yeon, Yeum, Kyung-Jin
- Journal of agricultural and food chemistry 2016 v.64 no.12 pp. 2492-2497
- DNA damage, black rice, blood glucose, blood serum, diet, droplets, dual-energy X-ray absorptiometry, fat body, gel electrophoresis, hyperglycemia, hyperlipidemia, insulin, kidneys, liver, mice, obesity, triacylglycerols
- Obesity is closely associated with metabolic disorders such as hyperglycemia and dyslipidemia. Leptin-deficient ob/ob mice (C57BL/6J-ob/ob) and C57BL/6J mice were randomly assigned to a diet of black rice with giant embryo (BR), white rice (WR), or AIN-93G (control) and pair-fed for 14 weeks. Although there was no significant difference in body weight, BR-fed ob/ob mice had (1) significantly lower body fat mass than WR- and control-fed ob/ob mice determined by dual-energy X-ray absorptiometry; (2) significantly lower blood glucose, serum insulin, and triacylglycerol levels than control-fed ob/ob mice; and (3) significantly lower liver weight, hepatic triacylglycerol, and hepatic lipid droplets than both WR- and control-fed ob/ob mice. Furthermore, DNA damage in the liver, determined by phosphorylated H2AX protein, and in the kidney, determined by single-cell gel electrophoresis, was significantly lower in BR-fed than WR- and control-fed ob/ob mice. This study indicates that BR ameliorates obesity and its related metabolic disorders.