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Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity

Author:
Pérez Recalde, Mercedes, Carlucci, María J., Noseda, Miguel D., Matulewicz, María C.
Source:
Phytochemistry 2012 v.73 pp. 57-64
ISSN:
0031-9422
Subject:
Dengue virus, Human herpesvirus 1, Nemalion, anticoagulant activity, antiviral properties, dimethyl sulfoxide, mannans, methylation, nuclear magnetic resonance spectroscopy
Abstract:
The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated with SO₃-pyridine in dimethyl sulfoxide at 60°C during two and three hours and the xylomannans were subjected to Smith degradation in order to eliminate xylose side-chains. Structural analysis of all derivatives was carried out by methylation analysis and ¹³C NMR spectroscopy. Antiviral activity against herpes simplex virus type 1 and 2, and dengue virus type 2 of native and modified mannans and xylomannans was estimated. Anticoagulant effect of the active fractions was also determined.
Agid:
522216