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Phylogeny and Biotransformation. Part 5*: Biotransformation of Isopinocampheol
- Abraham, Wolf-Rainer
- Zeitschrift für Naturforschung 2014 v.49 no.9-10 pp. 553-560
- Basidiomycota, Zygomycota, bacteria, biotransformation, enantiomers, fungi, monoterpenoids, oxidation, phylogeny, screening
- Biotransformation of isopinocampheol with 100 bacterial and fungal strains yielded 1-, 2-, 4-, 5-, 7-, 8 - and 9-hydroxy-isopinocampheol besides three rearranged monoterpenes, one of them bearing the novel isocarane skeleton. A pronounced enantioselectivity between (+)- and (-)-isopinocampheol was observed. The phylogenetic position of the individual strains could be seen in their ability to form the products from (+)-isopinocampheol. The formation of 1,3-dihydroxypinane is a domain of bacteria, while 3,5- or 3,7-dihydroxypinane was mainly formed by fungi, especially those of the phylum Zygomycotina. The activity of Basidiomycotina towards oxidation of isopinocampheol was rather low. Such informations can be used in a more effective selection of strains for screening.